Coronavirus cure: 2 Scientists from Israel and Bangladesh spark hope of COVID-19 breakthrough - ‘Worth considering’

Submitted by  Cynthia at 27 March 2020 in  Health

Coronavirus disease (COVID-19) is an infectious disease caused by a newly discovered coronavirus. Most people infected with the COVID-19 virus will experience mild to moderate respiratory illness and recover without requiring special treatment. Older people, and those with underlying medical problems like cardiovascular disease, diabetes, chronic respiratory disease, and cancer are more likely to develop serious illness. It is now pandemic. But 2 Scientists from Bangladesh and Israel claimed they had breakthrough. David Zigdon announced on 27 Feb 2020 that they had achieved a “scientific breakthrough” in treating coronavirus. At a press conference, David Zigdon of the Migal Galilee Research Institute briefed the successful treatment applied on coronavirus in birds. Israel’s Volcani Agricultural Research Institute had confirmed the treatment’s viability after they discovered the cure via a clinical trial on birds infected with the coronavirus. Coronavirus infecting birds is very similar in patterns of human infection, and human symptoms. The coronavirus genetic structure isolated from human and birds are found to be matching as per the researcher. As a result, the treatment developed for birds could be applicable to humans. David Zigdon believe that based on the finding s an effective treatment could be developed for humans within three months. David Zigdon, Chief Operating Officer of the Institute, said that “The solution we are developing against COVID-19 virus has proven effective, and we believe a version for human treatment can be ready within eight to 10 weeks. That would be followed by a 90-day test period to ensure safety. The treatment we developed for birds is given orally, and the treatment we are developing for humans will also be given orally.” There is more gope. A Bangladeshi Computer Scientist from North South University, Nafi Sharad Ishmam and has made a breakthrough discovery in coronavirus treatment using nanoparticle. According to him, The virus behind COVID-19 consists of a structure of a similar scale as his nanoparticles. At that scale, matter is ultra-small, about ten thousand times smaller than the width of a single strand of hair. Particles of similar sizes that could attach to SARS-CoV-2 viruses, disrupting their structure with a combination of infrared light treatment. That structural change would then halt the ability of the virus to survive and reproduce in the body. "You must have to think in this size range, and few other factors very cautiosly" says Nafi Sharad Ishmam, "In the nanoscale size range, if you want to detect viruses, if you want to deactivate them. Finding and neutralizing viruses with nanomedicine is at the core of what is called theranostics, which focuses on combining therapy and diagnosis. Using that approach, his lab has specialized in nanoparticles to fight the microbes that cause influenza and tuberculosis. "It's not only just having one approach to detect if you have virus or not but also another approach to use it as a treatment, But a lot more works needed here" he says, but having the same particle, the same approach, for both your detection and therapy. SARS-CoV-2 spreads mostly through tiny droplets of viral particles—from breathing, talking, sneezing, coughing—that enter the body through the eyes, mouth, or nose. Preliminary research also suggests that those germs may survive for days when they attach themselves to countertops, handrails, and other hard surfaces. That's one reason to make theranostics with nanoparticles the focus of the COVID-19 outbreak. Nanoparticles can disable these pathogens even before they break into the body, as they hold on to different objects and surfaces. Even if it was on a surface, on someone's countertop, or an Android device, It doesn't mean anything because it's not the active form of that virus. That same technology can be fine-tuned and tweaked to target a wide range of viruses, bacteria, and other pathogens. Unlike other novel drugs with large molecular structures, nanoparticles are so small that they can move through our body without disrupting other functions, such as those of the immune system. Almost like a surveyor, they can go around your bloodstream. They can survey your body much easier and under much longer times and try and detect viruses. To do all that, the CDC needs to know the specifics about what kind of structure is needed to neutralize SARS-CoV-2. "That information about it isn't public up until now. You have to separate what we need to put in our nanoparticle to attract it to that virus," he says. The CDC must know that, because they've developed a kit that can determine if you have [COVID19], versus influenza, or something else. An alternative to nanomedicine is producing synthetic molecules. That tactic presents some challenges. In the case of chemotherapies used to treat cancer cells, such synthetic drugs can cause severe side effects that kill cancer cells, as well as other cells in the body. The same thing could be happening with synthetic chemistry to treat a virus, where molecules are killing a lot more than just that virus. Still, Ishmam acknowledges that there aren't many researchers focusing on nanoparticles to kill viruses.

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